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Publications



Book Chapters

Mathematical concepts in pharmacokinetics and pharmacodynamics with application to tumor growth
to appear in "Nonautonomous dynamics in the life sciences" (Springer)
(with J. Schropp)

Peer-Reviewed Journals

2014

Anticancer combination effects of gemcitabine and Et-743 in-vitro
(with X. Miao and WJ. Jusko )

Modeling of delays in PKPD: classical approaches and a tutorial for delay differential equations
(with W. Krzyzanski, JJ. Perez-Ruixo and J. Schropp)
Journal of Pharmacokinetics and Pharmacodynamics. 2014;41(4):291-318

2013 and older

Solution and implementation of distributed lifespan models
(with J. Schropp)
Journal of Pharmacokinetics and Pharmacodynamics. 2013;40(6):639-650

General relationship between transit compartments and lifespan models
Journal of Pharmacokinetics and Pharmacodynamics. 2012;39(4):343-355
(with J. Schropp)

Multi-response model for rheumatoid arthritis based on delay differential equations in collagen-induced arthritic mice treated with an anti-GM-CSF antibody
Journal of Pharmacokinetics and Pharmacodynamics. 2012;39(1):55-65
(with T. Wagner, C. Plater-Zyberk, G. Lahu and J. Schropp)

Modeling of tumor growth and anticancer effects of combination therapy
Journal of Pharmacokinetics and Pharmacodynamics. 2009;36(2):179-197
(with A. Walz, G. Lahu and J. Schropp)


(=under construction, =submitted, =published/accepted)


Talks

PAGE 2012: Modeling of delayed phenomena in PKPD by delay differential equations of lifespan type

PhD Thesis

Modeling of Pharmacokinetics and Pharmacodynamics with Application to Cancer and Arthritis
Universität Konstanz, 2012

Poster

PAGE 2014: Solving Semi-Delay Differential Equations in NONMEM

AAPS 2013: Mechanism-Based Drug Interaction Model of Gemcitabine and Ecteinascidin (Et-743) in Pancreatic Cancer Cells

PAGE 2013: Solution and implementation of distributed lifespan models

PAGE 2011: A multi-response model for rheumatoid arthritis based on delay differential equations in collagen induced arthritis mice treated with an anti-GM-CSF antibody

Life Sciences - Bilder des Lebens 2009: Mathematik im Medikament / Mathematische Modellierung in der Medikamentenentwicklung


Articles for Magazines

2008

Uni'kon: Mathematik im Medikament